Autism

Facts of Autism Found in Peer-Reviewed Journals

1. Inflammation

hs-CRP inflammation levels in autistic children are extreme:

  • “Normal range”: <1.0 ng/mL
  • “Heart disease risk”: >3 ng/mL
  • “Autoimmune disease”: 20-80 ng/mL
  • Autism: 500+ ng/mL (extreme cases >1000 ng/mL)

Levels correlate with symptom severity.

2. Cerebral Blood Flow

Blood flow reductions in autistic children:

  • Frontal lobes: -42.7%
  • Basal nucleus: -24.9%
  • Temporal lobe: -22.8%

Autistic adults previously diagnosed show even worse perfusion.

3. Intestinal Permeability

43% of autistic children (9/21) show abnormal permeability. This allows undigested food particles, toxins, and bacteria to leak into bloodstream, triggering immune response and red blood cell clumping (Rouleaux formations).

Connecting the Dots: Scientific Linkage

Key Pathophysiology Chain:

  1. Increased intestinal permeability →
  2. Immune activation →
  3. Red blood cell aggregation →
  4. Decreased cerebral blood flow

Early intervention strategy: Screen newborns via hs-CRP test (requires only finger-prick blood). Continue biannually in non-verbal children or those with developmental delays.

Autism Prevalence & Current Challenges

Current U.S. rate: 1 in 31 births. No objective diagnostic tests/treatments in standard care. FDA-approved medications only address behavioral symptoms: Risperidone (Ages 5-16) and Aripiprazole (Ages 6-17).

Proposed Diagnostic Framework

  1. Combine behavioral tools like M-CHAT with: hs-CRP blood test, Sedimentation rate, Lipoprotein Phospholipase A2 (LpPlA2)
  2. Critical need for objective screening to prevent developmental delays

Scientific References

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